80% Silymarins(UV-VIS) / 80% Silymarins/30%(Silybins+Isosilybins) / Milk thistle extract

Specifications

High Quality Milk Thistle Extract 

Specification: 80% Silymarin UV, 30%(Silybins+Isosilybins)
Latin Name: Silybum marianum. (L.)Gaertner
Active Ingredient: Silymarin

Color: Brown yellow

Form: Powder
Part of used: Seed
Extract Method: Grain Alcohol
Product Introduction
Milk thistle originally is from Europe, the ingredient responsible for milk thistle's medicinal qualities is called silymarin. Silymarin is a flavonolignan that has been introduced fairly recently as a hepatoprotective agent, it is the most well known compound of the flavonoids, thanks to its well defined therapeutic properties, and in reality it is a mixture of three structural components: Silybin, silydianine and silychristine, studies in animals have shown that silymarin promotes the following activities:

Liver Cell Growth ------ Silymarin from milk thistle appears to promote the growth of some types of cells in the liver. Milk thistle is not used to prevent Hepatitis C Virus from causing liver disease. Rather, milk thistle is used with the hope that it would minimize the damage to the liver that HCV can cause.

Antihepatotoxic Activity ------ Studies suggest that silymarin from milk thistle can block various types of toxins from entering and injuring liver cells.

Antioxidation ------ Milk thistle Silymarin may be an effective "antioxidant, " which means milk thistle may help fight a destructive chemical process in the body known as "oxidation. " In oxidation, harmful substances produced in the body (called free radicals) can damage cells. Some studies suggest that milk thistle silymarin can prevent these substances from damaging liver cells.

Inflammation Inhibition ------ Milk thistle's Silymarin is thought to prevent inflammation (swelling) of the liver; This may be described as displaying anti-inflammatory properties.

Silybin is the major active constituent of silymarin, both in vitro and animal research suggest that silibinin has hepatoprotective (antihepatotoxic) properties that protect liver cells against toxins, has also demonstrated anti-cancer effects against human prostate adenocarcinoma cells, estrogen-dependent and -independent human breast carcinoma cells, etc.

Active Ingredients
Silymarin / Silybins

Product Specification
80% Silymarins (UV-VIS)
80% Silymarins/30% (Silybins+Isosilybins)
50% Silymarins/30% Silybins(HPLC)
60% Silymarins/30% Silybins(HPLC)
40% Silymarins /15% Silybin(Water-Soluble)

Molecular Structure of Silybin
Molecular formula: C25H21O10
Molecular weight: 481.43
CAS No.: 22888-70-6

Physiological Functions
Liver Diseases, acute, chronic hepatitis
Protect liver from toxins, heavy metals, alcohol, poisons
Anti cancer
Cholagogue
Fatty degeneration of the liver
Jaundice
Psoriasis
Uterine tonic, menstrual difficulties
Spleen, kidney, gall bladder tonic
Varicose veins

Toxicity
The acute toxicity of silymarin and silybin were investigated by oral and intravenous route in various animal species. No mortality or any signs of adverse effects were observed after silymarin at oral doses of 20 g/kg in mice and 1 g/kg in dogs.

The 50% lethal dose (LD50) after intravenous infusion values are 400 mg/kg in mice, 385 mg/kg in rats and 140 mg/kg in rabbits and dogs. These data demonstrate that the acute toxicity of silymarin is very low. Similarly, its subacute and chronic toxicity are very low; The compound is also devoid of embryotoxic potential.

Applications
Functional food and food additive
Herbal beverage ingredients
Pharmaceutical stuff

Dosage Information
Most clinical trials have used daily dosages of 420 to 480 mg silymarin, divided into two or three doses daily. Until the specific effects of each of the flavonolignans is known and products are available that contain standardized ratios of these components, the optimal dosage will remain unknown. Table 1 outlines the efficacy, safety, tolerability, dosage, and cost of milk thistle.